Showing posts with label CRISPR. Show all posts
Showing posts with label CRISPR. Show all posts

Wednesday, September 14, 2022

Based Pairs


A 'factory reset' for the brain may cure anxiety, drinking behavior, study suggests: Gene editing reverses brain genetic reprogramming caused by adolescent binge drinking 
May 2022, ScienceDaily

CRISPR Cocktail:
"Early binge drinking can have long-lasting and significant effects on the brain and the results of this study offer evidence that gene editing is a potential antidote to these effects, offering a kind of factory reset for the brain, if you will," 

via University of Illinois Chicago: Targeted epigenomic editing ameliorates adult anxiety and excessive drinking after adolescent alcohol exposure. John Peyton W. Bohnsack, et al. Science Advances, 2022; 8 (18) DOI: 10.1126/sciadv.abn2748


Researchers find CRISPR-Cas9 gene editing approach can alter the social behavior of animals
May 2022, phys.org

The old switcheroo:
"We were really surprised at the results," Albers said. "We anticipated that if we eliminated vasopressin activity, we would reduce both aggression and social communication. But the opposite happened."

via Georgia State University: Jack H. Taylor et al, CRISPR-Cas9 editing of the arginine–vasopressin V1a receptor produces paradoxical changes in social behavior in Syrian hamsters, Proceedings of the National Academy of Sciences (2022). DOI: 10.1073/pnas.2121037119


Image credit: No credits, a computer made it! But I call it "Lobotomy in Alaska", from Lexica's library.


Wednesday, April 6, 2022

Crispets


AKA - As In CRISPR-ing Your Pets

Xiaomi unveils CyberDog: A personable quadruped robot
Aug 2021, phys.org

Can recognize its owner by face. Which means it can recognize an intruder by its non-owner face. Also this: multiple cameras placed strategically over its body surface.

Also, and I know they didn't mean it, but the news outlet here (TechXplore) says "CyberDog is very similar in appearance to Boston Dynamics' Spot..." and there's a reason for that, which we all know. It's a good thing we're doing such a good job of stopping 12-year olds from pirating $50 video games, because we wouldn't want them to grow up and become entire countries (China) that steal $50 million dollars in research and development. 


Kawasaki’s Robot Ibex
Mar 2022, Spectrum IEEE

So, halfway between humanoid robots and wheeled robots, we wondered if there was an opportunity. That’s why we started developing Bex, a quadruped walking robot. We believe that the walking technology cultivated in the development of humanoid robots can definitely be applied to quadruped walking robots.


Novel approach to treating type 2 diabetes shows prolonged normal blood sugar levels after a single one-time procedure
Oct 2021, phys.org

"By taking cells from the patient and treating them, we eliminate the risk of rejection," Prof. Levenberg explained. 

Read "Engineered them," because that's what we're really doing, right?

via American Technion Society: Margarita Beckerman et al, GLUT4-overexpressing engineered muscle constructs as a therapeutic platform to normalize glycemia in diabetic mice, Science Advances (2021). DOI: 10.1126/sciadv.abg3947


Photosynthesizing algae injected into the blood vessels of tadpoles supply oxygen to their brains
Oct 2021, phys.org

German scientists have developed another method that allows tadpoles to "breathe" by introducing algae into their bloodstream to supply oxygen.

"The algae actually produced so much oxygen that they could bring the nerve cells back to life, if you will," says senior author Hans Straka of Ludwig-Maximilians-University Munich. "For many people, it sounds like science fiction, but after all, it's just the right combination of biological schemes and biological principles."

via Ludwig-Maximilians-University Munich: iScience, Özugur et al.: "Green oxygen power plants in the brain rescue neuronal activity" DOI: 10.1016/j.isci.2021.103158

No Man's Sky

Synthetic Biological Engineering and Plant Nanobionics:
Engineers create light-emitting plants that can be charged repeatedly
Sep 2021, phys.org

Using specialized nanoparticles embedded in plant leaves, MIT engineers have created a light-emitting plant that can be charged by an LED. After 10 seconds of charging, plants glow brightly for several minutes, and they can be recharged repeatedly.

Their first generation of light-emitting plants contained nanoparticles that carry luciferase and luciferin, which work together to give fireflies their glow. In the case of glowing plants, a light capacitor can be used to store light in the form of photons, then gradually release it over time using phosphor, a material that can absorb either visible or ultraviolet light and then slowly release it as a phosphorescent glow. The researchers used a compound called strontium aluminate, which can be formed into nanoparticles, as their phosphor. Before embedding them in plants, the researchers coated the particles in silica, which protects the plant from damage.

Infused through pores on the surface of the leaves, the particles accumulate in a spongy layer called the mesophyll, where they form a thin film that absorbs photons either from sunlight or an LED. They also showed that they could illuminate the leaves of a plant called the Thailand elephant ear, which can be more than a foot wide—a size that could make the plants useful as an outdoor lighting source.

via Massachusetts Institute of Technology: Pavlo Gordiichuk et al, Augmenting the living plant mesophyll into a photonic capacitor, Science Advances (2021). DOI: 10.1126/sciadv.abe9733


Scientists show how an enigmatic bacterium from the Gobi desert harvests solar energy
Feb 2022, phys.org

The new organism belongs to a rare bacterial genus called Gemmatimonas phototrophica, and it contained bacteriochlorophyll, a pigment related to chlorophylls found in plants. Analysis of its genome by a collaboration of European and British scientists suggested that this novel bacterium conducts an ancient form of photosynthesis.

via Diamond Light Source: Pu Qian et al, 2.4-Å structure of the double-ring Gemmatimonas phototrophica photosystem, Science Advances (2022). DOI: 10.1126/sciadv.abk3139


New technique improves directed evolution of microorganisms
Feb 2022, phys.org

(Matt Shipman article in the wild; he wrote a book about being a "public information officer", what some people might associate with a science journalist.)

They're using Inducible Directed Evolution (IDE), which sounds like a better way of programming a virus to make genetic changes to a bacteria, or whatever you like. Just another step on the ladder of artificial evolution.

via North Carolina State University: Ibrahim S Al'Abri et al, Inducible directed evolution of complex phenotypes in bacteria, Nucleic Acids Research (2022). DOI: 10.1093/nar/gkac094


Post Script:
Robot vacuum cleaner trained to dodge pet faeces
Sep 2021, BBC News

The real story here is that automatic lawnmowers can't identify hedgehog corpses.

Wednesday, July 19, 2017

Holy Bread

Salvador Dalí, Crucifixion (Corpus_Hypercubus), 1954

Dali wears bread on his head, 1958
Say What?
Vatican outlaws gluten-free bread for Holy Communion
July 2017, BBC

Bread used to celebrate the Eucharist during Roman Catholic Mass must not be gluten-free - although it may be made from genetically modified organisms, the Vatican has ruled.

In a letter to bishops, Cardinal Robert Sarah said the bread can be low-gluten. But he said there must be enough protein in the wheat to make it without additives.

The new rules are needed because the bread is now sold in supermarkets and on the internet, the cardinal said. [I don't understand; the Vatican sells its own brand of bread?]

Roman Catholics believe bread and wine served at the Eucharist are converted into the body and blood of Christ through a process known as transubstantiation.
-BBC

Every once in a while I forget that this is a real thing, like, during this particular ceremony the bread is -really- turned into the body of Christ. Really. Really?

But wait, you're telling me that the same entity that thinks its bread is turning into flesh is also making decisions about the validity of genetically modified organisms. CRISPR vs Christ?