Showing posts with label organoids. Show all posts
Showing posts with label organoids. Show all posts

Thursday, July 4, 2024

More Advances in Vision Tech


Nanostructured flat lens uses machine learning to 'see' more clearly, while using less power
Jan 2024, phys.org

Meta Imager - a lense that processes the image on the front-end, so it can be thinner and process more efficiently.

Vanderbilt University: Hanyu Zheng et al, Multichannel meta-imagers for accelerating machine vision, Nature Nanotechnology (2024). DOI: 10.1038/s41565-023-01557-2

Image credit: AI Art - What Does Sadness Look Like - 2022


Lab-grown retinas explain why people see colors dogs can't
Jan 2024, phys.org

Just Retinal Organoids - By tweaking the cellular properties of retinal organoids, the research team found that a molecule called retinoic acid (an offshoot of vitamin A) determines whether a cone will specialize in sensing red or green light. Only humans with normal vision and closely related primates develop the red sensor.

via Johns Hopkins University: Retinoic acid signaling regulates spatiotemporal specification of human green and red cones, PLoS Biology (2024). DOI: 10.1371/journal.pbio.3002464. 


A camera-based anti-facial recognition technique
Jan 2024, phys.org

Anti-Facial Recognition - obfuscating, synthesizing or changing images to increase the privacy of users

CamPro - whereas most techniques use post-processing to modify images after they were captured, this    technique works at the camera sensor level to produce images that can protect users' facial privacy without influencing other applications

Using a very simplified explanation - the team manipulated certain parameters at the signal processing layer of the camera, right after the sensor, to take away personal identifying information from the picture, but while leaving the other information like person detection and pose estimation. It works by adjusting the existing processing parameters, but without requiring redesigning the camera, and it's called "privacy-preserving by birth" (why not by design?).

What's more is that because the resulting image may not be "human readable", they put some code in there to make the face back into something that humans can see pretty good, yet doesn't have the data that a computer needs to see it. This is like how a stop sign with a picture of a banana on it can brick your self-driving car; it looks like a banana to you, or a mess of dots, or whatever, but to the computer it looks like something completely different and in fact makes the stop sign itself invisible.

via USSLAB at Zhejiang University: Wenjun Zhu et al, CamPro: Camera-based Anti-Facial Recognition, arXiv (2024). DOI: 10.48550/arxiv.2401.00151


Science fiction meets reality as researchers develop techniques to overcome obstructed views
Feb 2024, phys.org

Using an ordinary digital camera - "We're turning ordinary surfaces into mirrors to reveal regions, objects, and rooms that are outside our line of vision"

via University of South Florida: Robinson Czajkowski et al, Two-edge-resolved three-dimensional non-line-of-sight imaging with an ordinary camera, Nature Communications (2024). DOI: 10.1038/s41467-024-45397-7

AI Art - Vase of Golden Threads in Impossible Geometries by Escher and Lalique - 2022

Using 3D printing to make artificial eyeballs more quickly and accurately
Feb 2024, phys.org

Artificial eyeballs thought you knew

via Fraunhofer Institute for Computer Graphics Research at Technical University Darmstadt, NIHR Biomedical Research Centre for Ophthalmology at Moorfields Eye Hospital, UCL Institute of Ophthalmology: Johann Reinhard et al, Automatic data-driven design and 3D printing of custom ocular prostheses, Nature Communications (2024). DOI: 10.1038/s41467-024-45345-5


Pushing back the limits of optical imaging by processing trillions of frames per second
Mar 2024, phys.org

Femtophotography - trillions of frames per second, used for femtosecond laser ablation, shock-wave interaction with living cells, and optical chaos 

Optical Chaos - chaos generated by laser instabilities using different schemes in semiconductor and fiber lasers

via Énergie Matériaux Télécommunications Research Centre at INRS Institut National de la Recherche Scientifique, the Advanced Laser Light Source Laboratory, Institut Jean Lamour at the Université de Lorraine, and Huazhong University of Science and Technology: Jingdan Liu et al, Swept coded aperture real-time femtophotography, Nature Communications (2024). DOI: 10.1038/s41467-024-45820-z

 
AI-powered 'sonar' on smartglasses tracks gaze, facial expressions
Apr 2024, phys.org

Both use speakers and microphones mounted on an eyeglass frame to bounce inaudible soundwaves off the face and pick up reflected signals caused by face and eye movements. One device, GazeTrak, is the first eye-tracking system that relies on acoustic signals. The second, EyeEcho, is the first eyeglass-based system to continuously and accurately detect facial expressions and recreate them through an avatar in real-time.

via Cornell Smart Computer Interfaces for Future Interactions: Ke Li et al, GazeTrak: Exploring Acoustic-based Eye Tracking on a Glass Frame, arXiv (2024). DOI: 10.48550/arxiv.2402.14634


Advance in light-based computing shows capabilities for future smart cameras
Apr 2024, phys.org

A tiny array of transparent pixels could produce a fast, broadband, nonlinear response from low-power ambient light.

The thinness of the material makes it transparent, while it retains qualities that enable incoming photons to efficiently regulate electrical conductivity. The research team coupled the 2D semiconductor with a layer of liquid crystal and made it functional with an array of electrodes. The result is a smart filter comprising 10,000 pixels, each able to selectively and quickly darken in a nonlinear way when exposed to broadband ambient light.

"An inexpensive device measuring a couple of centimeters could make a low-powered camera work like a super-resolution camera"

via California NanoSystems Institute at UCLA: Dehui Zhang et al, Broadband nonlinear modulation of incoherent light using a transparent optoelectronic neuron array, Nature Communications (2024). DOI: 10.1038/s41467-024-46387-5

Thursday, April 6, 2023

The Science Fiction That Writes Itself


Human brain organoids implanted into mouse cortex respond to visual stimuli for first time
Dec 2022, phys.org

Mouse blood vessels grew into the organoid providing necessary nutrients and oxygen to the implant.
They are compatible, they latched on and are growing into the brain and working like normal brains.

I'll just copy the first paragraph exactly as-is, because this is what science fiction looks like as it's happening in real time:

A team of engineers and neuroscientists has demonstrated for the first time that human brain organoids implanted in mice have established functional connectivity to the animals' cortex and responded to external sensory stimuli. The implanted organoids reacted to visual stimuli in the same way as surrounding tissues, an observation that researchers were able to make in real time over several months thanks to an innovative experimental setup that combines transparent graphene microelectrode arrays and two-photon imaging.

via University of California San Diego: Madison N. Wilson et al, Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex, Nature Communications (2022). DOI: 10.1038/s41467-022-35536-3

Image credit: Jared Michael


Lab-grown retinal eye cells make successful connections, open door for clinical trials to treat blindness
Jan 2023, phys.org

Organoid photoreceptor cells can reach out toward new neighbors with characteristic biological cords called axons, and plug into other retinal cell types in order to communicate.

via University of Wisconsin-Madison: Allison L. Ludwig et al, Re-formation of synaptic connectivity in dissociated human stem cell-derived retinal organoid cultures, Proceedings of the National Academy of Sciences (2023). DOI: 10.1073/pnas.2213418120

Thursday, June 3, 2021

Full Steam Ahead


Mar 2021, phys.org

Behold, the most hardcore scifi illustration you've ever seen. 

I call it the kufizoid, because I envision it as a hat we will all wear, and it will be alive on its own, and we will live with it in symbiosis as it instantiates our autopoetic anthropic amalgam of splinter-selves. You might call it an embroidered lace jellyfish biobot that sucks itself to your head to control your brain. But no need to be afraid; you'll love it. 

But what exactly are we looking at in this picture above? Scientists first made mini-brains-in-a-dish, and then created this kufi-probe, outfitted with electrodes, heating elements, oxygen sensors and light fibers to perform optogenetic experiments where they can control genes with light pulses. This probe-hat fits nice and snug right on top of that little brain bubble that lives in a dish. 

One day, somewhere between now and the day we become brains in a dish ourselves, we will wear these devices on our heads, to monitor and control our cortical activity, and to synchronize us with each other, so we can build a fully dematerialized anthroposphere, and live there happily together. 

But let's continue: 
This platform then enabled scientists to perform complex studies of human tissue without directly involving humans or performing invasive testing. 
-source: phys.org
Obviously the value of such a device is that we can study the human brain while it's not inside a human head. But in reading this, we get a glimpse of what this investigative approach will really do for us in the future -- we will use it in tandem with synthetic body doubles, running simulations by the billions every second, and in real-time, to aid us in planning and executive function. Your synthetic body double will be networked to every other person's double, so that eventually, all our doubles will become more and more enmeshed with each other, not in the physical world with all its physical limitations, but in the network, aka the anthroposphere, where the only limitation is the speed of light. And then, there will be no more doubles; we will become the double. 

image credit: Northwestern University

Post Script:
Cortical spheroids used to be called cerebral organoids, so it now sounds a lot less heavy on the ethics scale. You might call it etymological camouflage. And "engineered assembloids" is even better. 


Friday, January 15, 2021

Cyborgs Among Us


Next-generation brain implants with more than a thousand electrodes can survive for more than six years
Apr 2020, phys.org

Get it straight - they're growing glass to implant into the brain.
Researchers have demonstrated the ability to implant an ultrathin, flexible neural interface with thousands of electrodes into the brain with a projected lifetime of more than six years.

25 micrometers thick with 360 electrodes.

Thermally grown layer of silicon dioxide less than a micrometer thick can ward off the hostile environment within the brain, degrading at a rate of only 0.46 nanometers per day

Because this form of glass is biocompatible, any trace amount that dissolves into the body should not create any problems of its own.

Next-gen organoids grow and function like real tissues
Sep 2020, phys.org

Read the whole article and watch the video. Jeez.

Intestinal organoids. They're bio-engineered miniature intestines using a an artificial gut-shaped microchannel. Mini-guts.

They make the substrate out of proteins already found in the gut, cross-linking them into a hydrogel and forming it from a laser printer-cutter. The substrate, or scaffold, is then seeded with intestinal stem cells, that know how to do nothing else but make an intestine. And they do.

Homeostatic mini-intestines through scaffold-guided organoid morphogenesis, Nature (2020). DOI: 10.1038/s41586-020-2724-8


A lab that reads—and writes—our dreams
Apr 2020, phys.org

Dormio is a glovelike device that allows researchers to communicate with sleeping subjects as they slip into hypnogogia - a fleeting semi-conscious state between wakefulness and sleep, by tracking heart rate, muscle tone and skin conductance, as well as playing a word or other audio sound as subjects drift into the transitional sleep stage.

Wednesday, July 8, 2020

Anthroids


Researchers create three-dimensional organoid models of human forebrain
Jan 2020, phys.org

For the same reason a true robotic nose will not exist, these organoids will not be conscious. Consciousness requires a whole body, not just a brain.

image source: Smithsonian