Further support for 40 Hertz. First, some backstory:
A decade after she launched a collaboration to study whether stimulating the brain's gamma rhythms could help people with Alzheimer's disease, Picower Professor Li-Huei Tsai delivered a lecture on the latest 40Hz sensory stimulation research to an audience of colleagues at MIT Feb. 27. ... The MIT team often refers to 40Hz stimulation as “GENUS” for Gamma Entrainment Using Sensory Stimulation. They are still exploring the cellular and molecular mechanisms that underlie GENUS’s effects.
There's a joke in the community that it's a great time to have Alzheimer's - if you're a mouse.
-MIT News Mar 2025, https://news.mit.edu/2025/evidence-40hz-gamma-stimulation-promotes-brain-health-expanding-0314
But there's another joke, which isn't actually a joke, that papers, about Alzheimer's specifically, omitting the word "mice" from the title end up being reported by journalists who also omit the word "mice" from their own titles, and leaving readers to believe the experiments were done for humans. [study link]
All that considered, more support for the 40 Hertz:
Successful 40-Hz auditory stimulation in aged monkeys suggests potential for noninvasive Alzheimer's therapy
Jan 2026, phys.org
The experimental group received one hour of 40-Hz auditory stimulation, using a 1-kHz pure tone, daily for seven consecutive days, and saw clearance of β-amyloid from the brain into the cerebrospinal fluid, which means it's leaving brain and the body. Effect persisted for over five weeks.
via Chinese Academy of Sciences Kunming Institute of Zoology: Wenchao Wang et al, Long-term effects of forty-hertz auditory stimulation as a treatment of Alzheimer's disease: Insights from an aged monkey model study, Proceedings of the National Academy of Sciences (2026). DOI: 10.1073/pnas.2529565123
Image credit: VR headset for a mouse for treating Alzheimers - Cornell - 2024
The image was found here at Cornell but the paper is here

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